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OPC UA based on Matrikon would presents this Error in activating session problem. 

The OPC UA that comes with Simit has another problem:OPCUA Interface will automatically disconnected after 2.5 to 3 minutes of program startup, and  OPCUA Interface-Client Disconnected occurs immediately when recieve a PLC Output Bool signal changed event.

I am currently using realvirtual.io 2021.06.1637. It seems that the problem still exists. Hope it can be solved soon.